ABSTRACT
ObjectiveTo explore the syndrome and treatment rules of traditional Chinese medicine （TCM） in treating chronic obstructive pulmonary disease （COPD） based on the medical literature and cases with the help of TCM inheritance support system platform （V2.5）， thus providing new ideas for TCM to treat COPD. MethodThe medical cases of TCM treating COPD were retrieved from China national knowledge infrastructure （CNKI）， Wanfang Database， and VIP China Science and Technology Journal Database. The medical cases that met the inclusion literature were collected in a new Word document， and then input into the TCM inheritance support system platform （V2.5） after data standardization. With the help of the algorithm carried by this software， the frequency statistics of "symptoms， syndrome types of TCM， Chinese medicine， and meridians of Chinese medicine" in the included COPD medical cases were performed， and the correlation analysis of the "prescription rules" in the included medical cases was carried out， thus excavating the potential core drug pairs and new prescriptions for the treatment of COPD. ResultA total of 103 articles were included with 126 medical cases and 131 diagnoses and treatments. According to statistics， the common symptoms of COPD were cough， expectoration， chest tightness， and asthma， and the common TCM syndromes included phlegm-heat obstructing lung， phlegm and blood stasis blocking lung， and lung-spleen Qi deficiency. The common TCM treatment methods included clearing heat and resolving phlegm， banking up earth to generate metal， and descending adverse and relieving dyspnea， among which the high-frequency Chinese medicines for the treatment of COPD were Pinelliae Rhizoma， Armeniacae Semen Amarum， Ephedrae Herba， Citri Reticulatae Pericarpium， and so on. The commonly used drug pairs included Asari Radix et Rhizoma-Pinelliae Rhizoma， Pinelliae Rhizoma-Schisandrae Chinensis Fructus-Glycyrrhizae Radix et Rhizoma， etc. Twelve new prescriptions for the treatment of COPD were found. ConclusionTCM believes that COPD is a lung disease formed by external evil， phlegm， blood stasis， and other pathological factors， with cough， phlegm， and asthma as the main symptoms. The main syndromes of COPD are phlegm-heat obstructing lung， phlegm and blood stasis blocking lung， and lung-spleen qi deficiency. "Strengthening the upright and dispelling evil" is the basic principle of the treatment COPD. In clinical， TCM methods with dispelling phlegm and removing blood stasis， and tonifying lung， spleen， and kidney should be adopted to treat COPD.
ABSTRACT
In this paper, nano-sponges of flavonoids from Glycyrrhizae Radix et Rhizoma (LF-NSP) were prepared by agitation-freeze drying method. Box-benhnken design and response surface method based on the single factor experiment was used to optimize the preparation process, with the stirring temperature as well as stirring time and speed as the independent variables, while with drug loading, particle size and the generalized "normalized value" as the response values. In addition, the nano-sponges were characterized by scanning electron microscope (SEM), infraredspectroscopy (FT-IR) and differential scanning calorimetry (DSC), and its release in vitro was also investigated. The results showed that the optimum preparation conditions for glycyrrhizin nano-sponges were as follows：The proportion of main drug and auxiliary drug was 1:2; the proportion of crosslinking agent DPC and β-CD was 4:1; stirring temperature 45 °C for 4.8 h at 245 r·min⁻¹. The comprehensive score of LF-NSP prepared under these conditions was 94.78. FT-IR and DSC results indicated the formation of Glycyrrhiza flavonoids nano-sponges, and SEM showed that they were spherical particles in shape. In release experiment in vitro, the cumulative release of glycyrrhizin flavonoids nano-sponges for 240 min was 81.8%, while that of crude drug was only 31.5%. Nano-sponges can significantly improve the dissolution of flavonoids from Glycyrrhizae Radix et Rhizoma.
Subject(s)
Animals , Drugs, Chinese Herbal , Flavonoids , Glycyrrhiza , Rhizome , Spectroscopy, Fourier Transform InfraredABSTRACT
Nanosuspension technology has provided a new method for improving the solubility and bioavailability of the effective components and the effective parts in Chinese materia medica (CMM). It is one of the effective ways to realize the modernization and internationalization in the application and development of CMM. This article mainly summarizes the preparation method, curing research, application of CMM nanosuspension drug delivery system, analyzes the existing problems, and puts forward some ideas, in order to promote the development and perfection of nanosuspension technology in CMM, and expand the scope of application of CMM.
ABSTRACT
<p><b>OBJECTIVE</b>To compare the content of momordin Ic and total saponin in K. scoparia fruits from eleven producing areas.</p><p><b>METHOD</b>HPLC-ELSD and colorimetric method were used to determine the content of momordin Ic and total saponin, respectively.</p><p><b>RESULT</b>The content of momordin Ic in K. scoparia fruits was related to that of total saponin. In the eleven kinds of K. scoparia fruits tested, those produced in Bozhou, Baoding Anguo and Heilongjiang contained more saponins.</p><p><b>CONCLUSION</b>The content of saponin in K. scoparia fruits from various areas is different, and attention must be paid to the effects of environment on the quality of herbs.</p>